The LSU Tigers and Ole Miss Rebels will meet in Oxford on Saturday afternoon. They both enter their big SEC showdown undefeated for the season and ranked in the top 15 in the country. Ole Miss has been explosive offensively, while LSU has leaned heavily on its defense to keep out of the loss column. Before this huge matchup kicks off, continue reading to get my LSU vs Ole Miss prediction.
Our LSU vs Ole Miss Pick
- Pick: Ole Miss -1.5
- Confidence: 4/5
Game Snapshot
- Matchup: LSU Tigers vs Ole Miss Rebels
- Date & Time: Saturday, September 27, 2025, 3:30 PM ET
- Venue: Vaught-Hemingway Stadium, Oxford, MS
- Broadcast: ABC
LSU vs Ole Miss Odds
| Spread | Moneyline | Total |
|---|---|---|
| Ole Miss −1.5 | Ole Miss −120, LSU +100 | 54.5 |
Key Storylines
- Quarterback situation at Ole Miss: Trinidad Chambliss has been efficient in his starts, having thrown for 307 yards and two touchdowns against Tulane with 17 completions on 27 attempts. He also added 112 rushing yards. He gives the Rebels a dual-threat option at quarterback. He has four touchdowns and no interceptions on the season.
- Garrett Nussmeier’s momentum: LSU senior QB Garrett Nussmeier has thrown for 962 yards, six touchdowns, and two interceptions this season. His recent performance vs Southeastern was impressive. He went 25/31 for 273 yards and three touchdowns. But the LSU offense hasn’t scored more than 23 points in a game against an FBS opponent this year.
- Offensive trends & balance: Ole Miss has scored at least 40 points in three of their four games to start the season. LSU’s offense has had a much tougher time getting up and running early in the year and will try to change that this week.
- Defensive concerns: Ole Miss’ defense struggled against Arkansas, but they bounced back nicely in their win at home over Tulane. LSU’s defense has been spectacular early in the season. But this is their biggest test of the season so far against the explosive offense of Ole Miss.
- Rivalry factor/previous meeting: Last season, LSU beat Ole Miss 29-26 in an overtime game. Ole Miss has home-field advantage this year and will try to avenge that loss.
Betting Trends & H2H
- LSU is 2-2 against the spread.
- Ole Miss is off to a 3-1 start against the spread this year.
- The Rebels have had three of their first four games go over their totals.
- LSU has had three of their first four games go under their totals.
LSU vs Ole Miss Model Projection
Score Projection: Ole Miss 31 – LSU 27
Win Probability: Ole Miss 55%, LSU 45%
Final Thoughts
Ole Miss comes in with more offensive firepower and home-field advantage. LSU has the more experienced quarterback in Nussmeier and a strong defense, but issues up front and a lack of production on the scoreboard against quality competition should trip them up here. I am going to take the Rebels to win and cover the spread at home, as Lane Kiffin’s team should remain unbeaten and get a statement win over another elite SEC opponent.
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- Source: https://ats.io/college-football/lsu-tigers-vs-ole-miss-rebels-pick-prediction-9-27-2025/468285/