The Cleveland Guardians will face the Baltimore Orioles in the second game of their four-game series on Tuesday night. The Guardians won the first game of this series thanks to some offensive fireworks at home. Cleveland is favored at home again tonight and has a chance to get back to the .500 mark for the season with a win. Continue reading to get my Orioles vs Guardians prediction for this Tuesday night contest in the American League.
Our Orioles vs Guardians Pick
- Pick: Guardians Moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Baltimore Orioles at Cleveland Guardians
- Date & Time: Tuesday, July 22, 2025, 6:40 p.m. ET
- Starting Pitchers: Brandon Young vs. Joey Cantillo
- Stadium: Progressive Field, Cleveland, OH
- Broadcast: CLEG and MASN2
Key Storylines
Pitching Form
Brandon Young has had a difficult season. He has an 0-4 record with a 7.52 ERA. Left-handed hitters have feasted on his pitching so far this year. He rarely goes beyond four innings and that could have an impact on the Baltimore bullpen tonight. Joey Cantillo has not been dominant this season. But he has been respectable, with a 4.17 ERA.
Bullpen Usage
The Orioles’ bullpen ranks among the worst in MLB and could be exposed if they are forced to enter for Young early on. Baltimore’s pen helped them to give up 10 runs in their loss to Cleveland last night and they could struggle again in this game.
Recent Team Streaks
Cleveland has won two straight games, including Monday’s 10‑5 romp over Baltimore. The Guardians have won four of their last five games. The Orioles limp into this game having dropped four of their last five. They will look to turn things around starting with a victory tonight.
Best Player Props
| Player | Prop | Pick |
|---|---|---|
| Jose Ramirez (CLE) | Home runs | Over 0.5 |
| Brandon Young (BAL) | Strikeouts | Under 4.5 |
| Gunnar Henderson (BAL) | Total bases | Over 1.5 |
Betting Trends & H2H
- The season series between these teams is tied 2-2 after Cleveland’s win on Monday.
- Baltimore is 21-24 in night games this season. The Guardians are 23-18 at night after Monday’s victory.
- The Guardians are a win away from getting back to the .500 mark both for the entire season and at home.
Orioles vs Guardians Model Projection
Score Projection: Guardians 5 – Orioles 3
Win Probability: Guardians 58%, Orioles 42%
Final Thoughts
The Guardians are playing very well of late and looking like they could make a push toward a Wild Card berth in the American League. I expect them to get back to .500 with a win tonight over a struggling Orioles team. Cleveland’s starting pitching advantage will be a big factor in this contest and should allow the Guardians to play from ahead for most of the night.
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- Source: https://ats.io/mlb/baltimore-orioles-vs-cleveland-guardians-prediction-7-22-2025/451053/