The Cleveland Guardians will take on the Baltimore Orioles in the second matchup of their four-game series on Tuesday night. The Guardians secured a win in the series opener with strong home performances. Cleveland is favored to win once more and can reach a .500 season record with a victory. Continue reading for my Orioles vs Guardians prediction for this Tuesday night clash in the American League.
Our Orioles vs Guardians Pick
- Pick: Guardians Moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Baltimore Orioles at Cleveland Guardians
- Date & Time: Tuesday, July 22, 2025, 6:40 p.m. ET
- Starting Pitchers: Brandon Young vs. Joey Cantillo
- Stadium: Progressive Field, Cleveland, OH
- Broadcast: CLEG and MASN2
Key Storylines
Pitching Form
Brandon Young has struggled this season with an 0-4 record and a 7.52 ERA. Left-handed batters have been particularly successful against him. He seldom pitches beyond four innings, which could strain Baltimore’s bullpen. Joey Cantillo, while not dominant, maintains a respectable 4.17 ERA.
Bullpen Usage
Baltimore’s bullpen ranks poorly in MLB and may be vulnerable if Young exits early. They conceded 10 runs in their previous loss to Cleveland and might face similar challenges tonight.
Recent Team Streaks
Cleveland has won two consecutive games, including Monday’s 10‑5 triumph over Baltimore. The Guardians have emerged victorious in four of their last five games, while the Orioles have lost four of their last five and aim to change course with a win tonight.
Best Player Props
| Player | Prop | Pick |
|---|---|---|
| Jose Ramirez (CLE) | Home runs | Over 0.5 |
| Brandon Young (BAL) | Strikeouts | Under 4.5 |
| Gunnar Henderson (BAL) | Total bases | Over 1.5 |
Betting Trends & H2H
- The season series stands at 2-2 following Cleveland’s win on Monday.
- Baltimore is 21-24 in night games this season, while the Guardians are 23-18 at night following Monday’s
- SCCG Management. The Gambling Industry’s Global Connector. Access Here.
- Source: SCCGManagement.com