The St. Louis Cardinals will travel to Oracle Park for a Monday night game against the San Francisco Giants. Both clubs are still in contention for a Wild Card spot in the National League, but their time to make up their deficit is running out. Here, I break down this important National League matchup on the diamond and bring you my Cardinals vs Giants prediction.
Our Cardinals vs Giants Pick
- Pick: Over 7.5
- Confidence: ★★★☆☆
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Game Snapshot
- Matchup: St. Louis Cardinals vs San Francisco Giants
- Date & Time: Monday, September 22, 2025, 9:45 PM EDT
- Starting Pitchers: Michael McGreevy (STL) vs Justin Verlander (SF)
- Stadium: Oracle Park, San Francisco, CA
- Broadcast: MLB.tv
Key Storylines
Pitching matchup
Michael McGreevy will get the start for the Cardinals in this game on the road. McGreevy is 7-3 for the season and has a 4.08 ERA. His strikeout rate is low, with just 53 strikeouts in 86 innings of work. But he will try to overcome that to deliver his team a key victory in this matchup. Justin Verlander will start this contest for the Giants. He is 3-10 but has a 3.75 ERA that is better than his record would suggest. Verlander will try to continue to bring his ERA down while delivering his team a big win tonight.
Recent team streaks
- The Cardinals have won three of their last five games and took two out of three games against the Milwaukee Brewers in their last series.
- The Giants lost three of four games to the Los Angeles Dodgers in their last series.
Best Player Props
| Player | Prop |
|---|---|
| Willy Adames | Over 1.5 Total Bases |
| Justin Verlander | Under 5.5 Strikeouts |
Betting Trends & H2H
- The Cardinals lead the season series against the Giants 2-1.
- The Cardinals are 32-43 on the road for the season.
- San Francisco is 38-37 in front of their home crowd this year.
Cardinals vs Giants Model Projection
Score Projection: Cardinals 3 – Giants 5
Win Probability: Cardinals 43%, Giants 57%
Final Thoughts
Both teams are in desperate need of a win here and it will be interesting to see how the pressure of this moment impacts them. Instead of relying on either side to outperform the other here, I am going to take the over in this game. McGreevy and Verlander have both had their struggles so far this year and we should see both lineups jump on them with their playoff lives on the line. This game should fall around eight or nine total runs and go over the total no matter who ends up getting the win in the Bay Area.
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- Source: https://ats.io/mlb/st-louis-cardinals-vs-san-francisco-giants-prediction-9-22-2025/467937/