The Seattle Seahawks and Arizona Cardinals will kick off Week 4 of the NFL season on Thursday Night Football. This NFC West showdown features two 2-1 teams jockeying for division positioning in a division that has been highly competitive early in the year. This is a huge game for the postseason hopes of these two teams and you can continue reading to get my Seahawks vs Cardinals prediction below.
Our Seahawks vs Cardinals Pick
- Pick: Seattle Seahawks ML (-110)
- Confidence: ★★★☆☆
Game Snapshot
- Matchup: Seattle Seahawks vs Arizona Cardinals
- Date & Time: Thursday, September 25, 2025, 8:15 p.m. ET
- Venue: State Farm Stadium, Glendale, AZ
- Broadcast: Prime Video
Seahawks vs Cardinals Odds
| Spread | Moneyline | Total |
|---|---|---|
| Seahawks −1.5 | Seahawks -110 / Cardinals −110 | Over/Under 43.5 |
Key Storylines
- Arizona lost running back James Conner for the season this past week. His absence removes a reliable rushing threat and short-yardage complement for Kyler Murray. The Cardinals will need backs like Trey Benson to fill the void left by Conner’s absence.
- Seattle’s defense has been stout through three games. They have not allowed more than 17 points in a game yet this season. Their pass rush and secondary have created pressure and turnovers and they will look to continue doing so this week.
- Special teams has given Seattle extra lifts, including in their win over New Orleans where a punt return for a touchdown by Tory Horton and a blocked punt helped them flip the momentum early.
- Both teams are 2-1 this season and their lone losses have come to the San Francisco 49ers. A win here will put the team that earns it in second place through four weeks and will be huge for the playoff hopes of the winning team.
Quarterback Play
Sam Darnold has looked more comfortable in Weeks 2 and 3 after a shaky start to 2025. He threw for 218 yards and two touchdowns against New Orleans, sitting out the fourth when Seattle had a big lead. His completion percentage and deep ball metrics are solid, and he has found wide receiver Jaxon Smith-Njigba 22 times through three games.
Arizona’s Kyler Murray is dangerous but he struggled in Week 3 with 159 passing yards and one touchdown. Without Conner, Arizona’s reliance on the pass and perhaps more predictable play-calling could make Murray more susceptible to pressure and turnovers. Seattle’s secondary and pass rush could make life difficult for Murray in clutch moments.
Betting Trends & H2H
- Both teams are 2-1 against the spread this season.
- Seattle has seen two of their first three games go over their totals.
- Arizona has gone under the total in two of their first three games.
- Arizona is 1-0 at home to start this season.
- Seattle is 1-0 on the road through three weeks.
Seahawks vs Cardinals Model Projection
Score Projection: Seattle Seahawks 24 – Arizona Cardinals 20
Win Probability: Seattle 53%, Arizona 47%
Final Thoughts
Both of these teams are 2-1 to start the year, but I think their identical records couldn’t be more different. Arizona’s two wins have come against two of the worst teams in the NFL in the Carolina Panthers and New Orleans Saints. They haven’t proven anything despite having a winning record to begin the year. I will take the Seahawks to win this Thursday night matchup and for Seattle to get their third win in a row.
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- Source: https://ats.io/nfl/seattle-seahawks-vs-arizona-cardinals-prediction-9-25-2025/468008/