The Red Sox dominated the Yankees in the 2025 regular season (9-4), but Game 2 of the Wild Card Series has a different tone with Carlos Rodón on the mound for New York. Our Red Sox vs. Yankees predictions lean toward the Yankees moneyline, as Aaron Judge looks poised to deliver after a quiet Game 1.
Beyond this rivalry, Wednesday’s MLB Wild Card Games feature strong betting angles in Reds vs. Dodgers, Padres vs. Cubs, and Tigers vs. Guardians. We’ve highlighted moneyline and run line picks, along with a few player props, to give you options for both best bets and riskier parlays.
Disclaimer: Sports betting outcomes are unpredictable. These picks are based on available data and analysis, but no outcome is guaranteed.
Red Sox vs. Yankees – Yankees Lean on Rodón and Judge
Boston took Game 1 thanks to Garrett Crochet’s dominant pitching, but the Yankees now turn to Carlos Rodón (18-9, 3.09 ERA) at Yankee Stadium. Despite the Red Sox winning the season series 9-4, Rodón’s consistency and Judge’s power bat tilt Game 2 in New York’s favor. Judge posted a .331 AVG with 53 homers this season, and betting on him to go Over 1.5 total bases is supported by his track record against Boston pitching.
Reds vs. Dodgers – Yamamoto to Control the Mound
The Dodgers’ bats erupted for 10 runs in Game 1, and now they hand the ball to Yoshinobu Yamamoto (12-8, 2.49 ERA). The Reds struggled to contain Shohei Ohtani and Freddie Freeman, and their pitching depth looks thin. With Yamamoto’s strikeout ability, the Dodgers -1.5 run line and Yamamoto Over 6.5 strikeouts are logical plays.
Padres vs. Cubs – Cease Strikeout Angle
San Diego faces elimination on the road, with Dylan Cease (4.55 ERA) under pressure to redeem himself. The Cubs, however, boast one of the best home records (50-31) and showed sharp defense in Game 1. Justin Steele or the Cubs’ bullpen depth provides enough support for a moneyline play. With San Diego’s road struggles, the Cubs’ team total Over 3.5 runs has value.
Tigers vs. Guardians – Riley Greene at the Plate
Game 1 was a low-scoring 2-1 contest, and Game 2 could follow suit. Detroit sends Casey Mize (14-6, 3.87 ERA), while Cleveland counters with Tanner Bibee (12-8, 4.24 ERA). With both teams favoring tight, contact-heavy baseball, the Guardians’ home-field edge makes them the lean. The Under 7.5 runs aligns with recent trends in their matchups.
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- Source: https://sportshandle.com/red-sox-vs-yankees-predictions-more-mlb-wild-card-game-2-best-bets/