Former Super Bowl champion Kansas City Chiefs find themselves in uncharted territory, opening the 2025 season at 0-2 for the first time in the Patrick Mahomes era. That’s why they desperately need to win, and our pick is for Kansas to cover the spread against the New York Giants. But NFL Week 3 brings more on Sunday, including Cowboys vs. Bears, Cardinals vs. 49ers, Packers vs. Browns, and Eagles vs. Rams.
We’ve put together our best bets for today, highlighting parlays, moneyline plays, and player props as part of our NFL picks and predictions. Both expert and AI projections are included to provide different perspectives.
*As always, keep in mind that sports betting is unpredictable – these are suggestions based on analysis, not guarantees.
Kansas City Chiefs vs. New York Giants – Mahomes to Bounce Back
The Chiefs are desperate for their first win of the season, and Mahomes remains the focal point of the offense. New York, at 0-2, continues to struggle with a shaky offensive line. Historically, the Giants have the upper hand (11-4 record vs. Kansas City), but this is a very different era. The Chiefs’ spread pick makes sense given the gap in roster strength, while Mahomes going over 260 passing yards is supported by his consistent volume through two weeks.
Dallas Cowboys vs. Chicago Bears – Prescott and Lamb Connection
Dallas sits at 1-1, while rookie QB Caleb Williams is still finding his footing in Chicago. The Bears’ secondary has injury concerns, leaving them vulnerable to big plays. That’s why our expert pick leans Cowboys on the moneyline. AI suggests a CeeDee Lamb anytime touchdown, which aligns with the Bears’ defensive weaknesses against elite receivers.
Arizona Cardinals vs. San Francisco 49ers – Murray to Keep It Close
Both teams are 2-0, but the Cardinals have looked sharper than expected, led by Kyler Murray and rookie Marvin Harrison Jr. San Francisco has key injuries, including safety Malik Mustapha, which hurts their defense. Given Arizona’s strong start, covering the +2.5 spread is realistic. Murray’s mobility and red-zone usage also make an anytime TD a solid AI-backed play.
Green Bay Packers vs. Cleveland Browns – Packers’ Edge
Green Bay has opened 2-0 with Jordan Love commanding the offense well. Cleveland, meanwhile, is 0-1 and still adjusting after a tough 2024 season. Myles Garrett remains a defensive threat, but the Browns’ offense lacks consistency. Packers on the moneyline looks like the safer bet, while under 42.5 points fits the expectation of a defensive battle.
Philadelphia Eagles vs. Los Angeles Rams – Clash of NFC Contenders
The Rams are 2-0 but face their toughest challenge yet in the Super Bowl champion Eagles. Jalen Hurts and the Eagles offense have plenty of weapons, and the defense has proven capable against elite teams. The moneyline pick on Philadelphia reflects their balance, while AI favors Hurts as an anytime TD scorer – a play supported by his continued usage in the red zone.
Use Playbook to Make Your Sunday Football Picks
Action Network has recently launched Playbook, an AI-powered bot that builds betslips automatically from text or screenshots. If you see an appealing bet – say Chiefs vs. Giants – on X or Discord, tag @Playbook to instantly generate a betslip that you can place in seconds.
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- Source: https://sportshandle.com/picks-and-predictions-for-nfl-week-3-9-21-chiefs-vs-giants-cowboys-vs-bears/