Picks and Predictions NFL TNF: Seahawks vs. Cardinals

Fahad Umar
September 25, 2025
12:45 pm

While both the Seattle Seahawks and the Arizona Cardinals enter the NFL Week 4 TNF game with identical 2-1 records and a chance to climb the division standings, the historical matchup tells a one-sided story. The Seahawks have dominated the series, winning seven straight games over the Cardinals, a streak that dates back to the 2021 season.

With Seattle’s defense ranked second in scoring and Arizona struggling for consistency on offense, our picks and predictions lean toward the Under, while also spotlighting some intriguing player props and same-game parlays. In this article, we’ve gathered both expert and AI-driven NFL betting picks to give you a full breakdown of tonight’s Seahawks vs. Cardinals matchup.

*Remember: sports betting is unpredictable. These are just suggestions based on team form, matchups, and available data.

Seahawks vs. Cardinals TNF Match Overview

The Seahawks enter this game with a 2-1 record, riding high after a commanding 44-13 win over the Saints. Sam Darnold has looked sharp under new head coach Mike Macdonald, supported by breakout performances from Jaxon Smith-Njigba and rookie Tory Horton.

While the Seahawks’ rushing attack has been inconsistent, Kenneth Walker III has still found the end zone three times. Most importantly, Seattle’s defense has been dominant, allowing just 2.0 points per game, the second-lowest in the league.

For the Cardinals, injuries are the main storyline. They’ll be without RB James Conner for the season, putting Trey Benson in the spotlight. QB Kyler Murray has produced, but will need more help from his offensive line, which could be reshuffled due to several questionable players.

Historically, Arizona has struggled in this rivalry, losing the last seven meetings to Seattle. Their defense, however, remains a strength, especially against the run, which could be a factor against Walker and the Seahawks’ ground game.

Under 43.5 Total Points

Seattle’s elite defense, combined with Arizona’s offensive challenges, makes the Under a strong consideration. The Seahawks’ defensive front has generated turnovers and smothered opponents, while the Cardinals are still searching for rhythm with a banged-up offensive line and no James Conner. Even with Kyler Murray’s mobility, sustained drives could be difficult. Pair that with the Seahawks’ ability to control tempo, and Under 43.5 looks like one of the best bets tonight.

Jaxon Smith-Njigba Over 68.5 Receiving Yards

Smith-Njigba has emerged as Seattle’s go-to target, already racking up 323 receiving yards through three games. With the Cardinals’ secondary dealing with injuries and their defense stronger against the run than the pass, Darnold should lean on Smith-Njigba in key spots. His route-running and ability to gain yards after the catch give this prop strong value for bettors looking at player props tonight.

Seahawks to Win

Seattle has owned this rivalry, winning the last seven head-to-head meetings, and enters this matchup with better form on both sides of the ball. The Cardinals’ offensive line concerns and lack of a proven ground game without Conner put added pressure on Murray. Meanwhile, the Seahawks’ defense and balanced offensive weapons position them well to extend their winning streak. The AI model gives the Seahawks a clear edge here.

Kenneth Walker III Anytime TD

Despite inconsistencies in the run game, Walker remains Seattle’s most reliable red-zone weapon with three touchdowns already this season. The Cardinals’ defense is stout against the run, but Seattle uses Walker creatively near the goal line, increasing his scoring chances. For bettors willing to take on slightly higher risk for good value, Walker finding the end zone is a strong player prop to consider.

Use Playbook to Make Seahawks vs. Cardinals Picks

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