The Philadelphia 76ers and Chicago Bulls will meet in a huge Eastern Conference matchup in the NBA on Tuesday night. Both of these teams have identical 5-1 records and have been very impressive early on. But only one of them can come away with a win in Chicago here. Before tip-off from United Center, you can find my 76ers vs Bulls prediction below.
Our 76ers vs Bulls Pick
- Pick: Over 240.5
- Confidence: 3/5
Game Snapshot
- Matchup: Philadelphia 76ers @ Chicago Bulls
- Date & Time: Tuesday, November 4, 2025, 8:00 PM ET
- Venue: United Center, Chicago, Illinois
- Broadcast: NBA League Pass
Key Storylines
Both squads are off to 5-1 starts despite major injury concerns. The Bulls are 4-0 at home and looking to lean into their advantage at United Center. The 76ers arrive in Chicago on a three-game road win streak to start the season. Something has to give in this matchup in terms of those unbeaten starts at home and on the road.
Injuries will continue to impact these teams going into this game. Chicago will be missing Zach Collins and Coby White, with Ayo Dosunmu listed as questionable. The Sixers’ big absence is Paul George, while we could see Jared McCain suit up for Philadelphia after he missed some time to begin the year.
Philadelphia’s guard duo of Tyrese Maxey (33.7 PPG, 9.0 APG) and V.J. Edgecombe (20.3 PPG) have carried a heavy load for Philly given all of the uncertainty for them to start this season. The Bulls have enjoyed a very nice start from Josh Giddey (22.2 PPG, 8.7 APG). But both teams have received contributions from role players, who could make the difference again in this game.
Head-to-Head & Betting Trends
- This is the first meeting between these teams in the regular season. They will play three times total.
- Both of these teams are 5-1 against the spread to start the season. They are tied for the best ATS record in the NBA early in the year.
- Philadelphia has gone over the total in five of its first six games.
- Chicago has gone over the total in four of its first six games.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Tyrese Maxey | Over 27.5 points |
| V.J. Edgecombe | Under 16.5 points |
| Josh Giddey (Bulls) | Over 21.5 points |
76ers vs Bulls Model Projection
Score Projection: 76ers 125 – Bulls 129
Win Probability: Philadelphia 44%, Chicago 56%
Final Thoughts
Instead of betting against either of these red-hot teams, my best bet for this game is for the over to cash. The total is sky-high for this game, but that is justified given how effective both teams have been on offense to start the year. I’ll bank on both teams to light up the scoreboard in what could be the best game of the night in the NBA.
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- Source: https://ats.io/nba/philadelphia-76ers-vs-chicago-bulls-prediction-11-4-2025/473857/