The main event of conference championship weekend in college football will take place when the Indiana Hoosiers (12‑0) square off against the Ohio State Buckeyes (12‑0). Both teams arrive unbeaten, both with national championship hopes, and both with Heisman Trophy-quality quarterbacks. The winner of this game will go into the College Football Playoff as the top seed. Before number one and number two battle for the Big Ten title, you will find my Indiana vs Ohio State prediction below.
Our Indiana vs Ohio State Pick
- Pick: Indiana +4.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Indiana Hoosiers vs Ohio State Buckeyes
- Date & Time: Saturday, December 6, 2025, 8:00 PM ET
- Venue: Lucas Oil Stadium, Indianapolis, IN
- Broadcast: FOX
Indiana vs Ohio State Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Indiana Hoosiers | +4.5 | +170 | Over 48.5 |
| Ohio State Buckeyes | -4.5 | -205 | Under 48.5 |
Key Storylines
- Both squads enter this game at 12‑0, the last two remaining unbeaten teams in FBS. The winner grabs an automatic berth into the College Football Playoff, likely as the top seed. Indiana is playing in its first-ever conference championship game, while Ohio State is aiming to reclaim Big Ten championship glory yet again.
- The spotlight on the quarterbacks in this game could not be brighter. For Indiana, Fernando Mendoza has put up 2,758 passing yards, 32 touchdowns, and 5 interceptions. He is one of the leading contenders for the Heisman. Ohio State’s Julian Sayin has 3,065 passing yards, 30 touchdowns, and 5 interceptions. The quarterback that leads his team to a win in this game could end up winning the Heisman as well.
- Offense vs Defense: Indiana brings a high‑powered offense into this game, averaging 44.3 points per game for the season. Ohio State enters with the top defense in the FBS, yielding just 7.8 points per game and ranking first nationally in both passing defense and total defense. That will be an interesting strength-on-strength matchup.
- Ohio State has dominated this series historically (81–12–5) and Indiana has not beaten OSU since 1988. That drought will motivate the Hoosiers and provide some confidence for the Buckeyes, but this game could change all of that.
Betting Trends
- Ohio State is 10-1-1 against the spread going into this game.
- Indiana went 7-5 against the spread during the regular season.
- The Hoosiers have gone over the total in 7 of their 12 games.
- The under has cashed in 8 of its 12 games going into championship weekend.
Indiana vs Ohio State Model Projection
Score Projection: Indiana 27 – Ohio State 30
Win Probability: Indiana 34%, Ohio State 66%
Final Thoughts
This is the game of the year in college football so far and I think we are going to get an instant classic in Indianapolis. I think that Indiana will look better offensively than anyone else has against the Ohio State defense this season. But I think that Ohio State will win with a late field goal. My best bet for the game is for Indiana to cover the number as an underdog, in what could be a preview of the national championship game in just over a month.
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- Source: https://ats.io/college-football/indiana-hoosiers-vs-ohio-state-buckeyes-prediction-12-6-2025/477842/