The Cleveland Guardians will host the Detroit Tigers in the second game of a three-game series on Wednesday evening. Cleveland took the first game of this series and moved to the top of the AL Central standings via tiebreaker as a result. The Tigers are in a tailspin and will try to avoid further collapse in the standings with a win tonight. Before the first pitch from Cleveland, continue reading to get my Tigers vs Guardians prediction.
Our Tigers vs Guardians Pick
- Pick: Guardians ML
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Detroit Tigers @ Cleveland Guardians
- Date & Time: Wednesday, September 24, 2025, 6:40 pm ET
- Starting Pitchers: Tanner Bibee (CLE) vs Jack Flaherty (DET)
- Stadium: Progressive Field, Cleveland, OH
- Broadcast: CLEG and FDSDET
Key Storylines
Pitching matchup
Tanner Bibee enters with respectable stats. He has 157 strikeouts, a 1.23 WHIP, and a 4.34 ERA in 2025. He’s shown flashes of dominance, including a recent two-hit shutout. But his consistency under pressure will be tested in this high-leverage setting with the division lead on the line.
Jack Flaherty has had an up-and-down season for the Tigers. He is 8‑14 with a 4.60 ERA and his recent form is a bit shaky. In his last five starts, he’s posted a 5.04 ERA with 20 strikeouts. Comparatively, the edge goes slightly to Cleveland. Bibee’s ability to induce swings and misses and limit damage gives the Guardians a higher floor.
Recent Team Streaks
Cleveland is surging, going 17‑5 in September, moving them to the top of the AL Central standings. Meanwhile, Detroit has collapsed over the final stretch, losing seven straight games entering this matchup and surrendering a division lead that was once 11 games early in September. Cleveland is playing much better baseball of late and will try to keep it that way here.
Best Player Props
| Player | Prop Type | Pick |
|---|---|---|
| Jack Flaherty | Strikeouts | Under 5.5 |
| Tanner Bibee | Strikeouts | Over 5.5 |
| Jose Ramirez | Home Runs | Over 0.5 |
Betting Trends & H2H
- Cleveland leads the season series 7-4 over the Tigers this year.
- The Guardians have clinched the head-to-head season series victory over the Tigers with Tuesday’s win. That could be huge in the event of a tiebreaker scenario at the end of the regular season.
- Cleveland has won the last four games between these division rivals.
Tigers vs Guardians Model Projection
Score Projection: Tigers 4 – Guardians 5
Win Probability: Tigers 48%, Guardians 52%
Final Thoughts
All of the momentum is on Cleveland’s side heading into this contest. The Guardians are playing better baseball and have a slightly more consistent starting pitcher on the mound. I’ll go with Cleveland to hand the Tigers their eighth straight loss and for the Guardians to move even closer to completing one of the great comebacks in MLB regular season history.
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- Source: https://ats.io/mlb/detroit-tigers-vs-cleveland-guardians-prediction-9-24-2025/468243/