The Cleveland Cavaliers will visit the Indiana Pacers on Monday night in a game featuring two teams going through very different streaks. The Cavs have dropped a few games in a row, while the Pacers have finally strung a pair of wins together. Before these Central Division rivals meet in Indy, I’ll make my Cavaliers vs Pacers prediction here, as I tell you whether I think the Pacers can upset the Cavs at home.
Our Cavaliers vs Pacers Pick
- Pick: Cavaliers −6.5
- Confidence: 4/5
Bet $5, Get $200 in Bonus Bets If Your First Bet Wins
???? Parlay Profit Boosts
???? TD Scorer Profit Boosts
???? SEC Profit Boosts
Game Snapshot
- Matchup: Cleveland Cavaliers @ Indiana Pacers
- Date & Time: Monday, December 1, 2025, 7:00 PM ET
- Venue: Gainbridge Fieldhouse, Indianapolis, Indiana
- Broadcast: NBA League Pass
Cavaliers vs Pacers Odds
| Odds | Cleveland | Indiana |
|---|---|---|
| Spread | −6.5 | +6.5 |
| Moneyline | −250 | +205 |
| Total (O/U) | 232.5 | |
Key Storylines
- Cleveland is coming off a tough loss to the Boston Celtics and enters this game looking to snap a three‑game skid. Their offense typically runs through elite perimeter shooting and ball movement. But the Cavs will have to find a way to perform on the second game of a back-to-back here and that could cause problems for them on the road.
- Both teams are dealing with a ton of injury issues. The Pacers are without Tyrese Haliburton for the season, while Obi Toppin and Aaron Nesmith are also out. Cleveland is set to be without Jarrett Allen and Larry Nance Jr., while the status of Sam Merrill, Lonzo Ball, and Max Strus is up in the air.
- For Cleveland, their three‑point shooting is a major strength. They are among the league leaders in made threes per game, and with very little resistance outside from Indiana, perimeter shooting could help them build a comfortable lead despite being at a rest disadvantage.
Head-to-Head & Betting Trends
- The Cavs defeated the Pacers 120-109 in their first meeting of the regular season.
- Cleveland is 6-15 against the spread going into this matchup.
- The Pacers are 11-9 against the spread entering Monday night.
- The under has cashed in 12 of the 21 games for the Cavs this season.
- Indiana has gone under the total in 13 of their first 20 games.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Donovan Mitchell | Over 28.5 Points |
| Pascal Siakam | Over 23.5 Points |
Cavaliers vs Pacers Model Projection
Score Projection: Cavaliers 120 – Pacers 106
Win Probability: Cavaliers 70%, Pacers 30%
Final Thoughts
The Cavs are at a rest disadvantage going into this game. But they have huge advantages just about everywhere else against the Pacers in this matchup. I’m going to lay the points with the Cavaliers in this game, as they should bounce back from their loss to the Celtics to split their back-to-back coming out of Thanksgiving.
Affiliate Disclosure
ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
- SCCG Management. The Gambling Industry’s Global Connector. Access Here.
- Source: https://ats.io/nba/cleveland-cavaliers-vs-indiana-pacers-prediction-12-1-2025/477658/