The headliner in Week 1 of the NFL season comes on Sunday Night Football. The Baltimore Ravens and Buffalo Bills played an epic in the Divisional playoffs last season. Buffalo came out on top at home in that game and they will look to defeat the Ravens in Orchard Park once again here. Baltimore will have revenge on the brain going into this postseason rematch. Before the action begins between Baltimore and Buffalo, continue reading to get my Ravens vs Bills prediction.
Our Ravens vs Bills Pick
- Pick: Baltimore Ravens +1.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Baltimore Ravens vs Buffalo Bills
- Date & Time: Sunday, September 7, 2025, 8:20 PM ET
- Venue: Highmark Stadium, Buffalo, NY
- Broadcast: NBC
Ravens vs Bills Odds
| Betting Market | Odds |
|---|---|
| Spread | Bills -1.5 |
| Moneyline | Bills -115 / Ravens -105 |
| Total | Over/Under 50.5 |
Key Storylines
- Ravens’ Offensive Firepower: Quarterback Lamar Jackson enters his third season under offensive coordinator Todd Monken. He aims to build on a season where he threw for 3,200 yards and 28 touchdowns. The addition of wide receiver DeAndre Hopkins provides another reliable target and Derrick Henry remains a threat on the ground for Baltimore.
- Bills’ Defensive Concerns: The Bills’ defense faces challenges with key injuries. Cornerback Tre’Davious White is one of the starters for the Bills that is questionable for this game. White being compromised could compromise their ability to contain the Ravens’ high-powered offense. Their secondary depth will be tested against Baltimore’s versatile passing game.
- Playoff Rematch: The Bills beat the Ravens in the Divisional playoffs last season. A dropped two-point conversion by Mark Andrews ended a late comeback attempt by Baltimore in that game. Baltimore could be better now that Lamar Jackson isn’t dealing with playoff pressure in this contest.
Quarterback Play
Lamar Jackson is coming off a season where he led the Ravens to a 12–5 record but his team fell short in the playoffs again. Not all of Baltimore’s playoff struggles have been Jackson’s fault and he was very good against the Bills in the playoffs last year. But this season is another defining year for Jackson’s legacy as he looks to prove doubters wrong in big games.
Josh Allen continues to be the centerpiece of the Bills’ offense. He won the NFL MVP award last season over the aforementioned Jackson. He will have to overcome injury concerns for wide receiver Khalil Shakir to deliver another strong performance against the Ravens.
Best Player Props
| Player | Prop |
|---|---|
| Lamar Jackson | Over 1.5 Passing Touchdowns |
| Derrick Henry | Over 82.5 Rushing Yards |
| Josh Allen | Anytime Touchdown Scorer |
| Josh Allen | Over 0.5 Interceptions |
Betting Trends & H2H
- The Ravens are 7–2 against the spread in their last nine Week 1 games.
- The Bills have won 11 of their last 13 games as favorites.
- The total has gone over in 14 of the Ravens’ last 19 games.
- These teams went 1-1 against each other last season. Baltimore beat Buffalo in the regular season before the Bills returned the favor in the playoffs.
Ravens vs Bills Model Projection
- Score Projection: Ravens 28 – Bills 24
- Win Probability: Ravens 55%, Bills 45%
Final Thoughts
I don’t think we should put too much stock into the Bills beating the Ravens in the playoffs last year. That game was incredibly close and was in a freezing cold Buffalo during the playoffs. The warmer weather will help Lamar Jackson play to his full potential and the addition of Hopkins won’t hurt him either. Jackson has already proven he can beat the Bills in the regular season and I think the Ravens will do so again here.
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- Source: https://ats.io/nfl/baltimore-ravens-vs-buffalo-bills-prediction-9-7-2025/464974/